As Acronis Drive Cleanser 6.0 does not actually require an operating system, it will work with disks of any size supported by the BIOS of your computer.
For information on what operating systems are supported by Acronis Drive Cleanser 6.0 please see Operating Systems Acronis Drive Cleanser 6.0 Supports.
For information on what file systems are supported by Acronis Drive Cleanser 6.0 please see File Systems Acronis Drive Cleanser 6.0 Supports.
