Use either of the following methods or both.
Install Acronis software onto the virtualization host
This approach comes in handy when the virtualization product installed on the host server is VMware ESX(i) or Windows Server 2008 with Hyper-V or Microsoft Hyper-V Server.
You will be able to back up entire virtual machines or their volumes using a single subscription for virtual machines. The subscription applies to all machines hosted on the host or to the entire vCenter cluster. File-level backup and recovery is not possible for virtual machines, but is possible for a Windows host.
Installing the software, backing up, and recovery are described in the "Backing up Virtual Machines" document for Acronis Backup & Recovery 11 Virtual Edition. When installing Acronis Backup & Recovery 11 for online backup only, you do not need to enter a license key during installation.
Host-based backup is available only for paid licenses of VMware ESXi. Choose the below approach if your ESXi Server uses a free license.
Install Acronis software into the guest system
The machine will be treated as a physical one. You will need a separate server or workstation subscription for this machine. This approach comes in handy when:
Installing the software, backing up, and recovery are the same as with a physical machine.