Application-aware disk-level backup is available for physical machines and for ESXi virtual machines.
When you back up a machine running Microsoft SQL Server, Microsoft Exchange Server, or Active Directory Domain Services, enable Application backup for additional protection of these applications' data.

Why use application-aware backup?
By using application-aware backup, you ensure that:
What do I need to use application-aware backup?
On a physical machine, Agent for SQL and/or Agent for Exchange must be installed, in addition to Agent for Windows.
On a virtual machine, no agent installation is required; it is presumed that the machine is backed up by Agent for VMware (Windows).
Agent for VMware (Virtual Appliance) and Agent for VMware (Linux) can create application-aware backups, but cannot recover application data from them. To recover application data from backups created by these agents, you need Agent for VMware (Windows), Agent for SQL, or Agent for Exchange on a machine that has access to the location where the backups are stored. When configuring recovery of application data, select the recovery point on the Backups tab, and then select this machine in Machine to browse from.
Other requirements are listed in the "Prerequisites" and "Required user rights" sections.